Publications

81. Redox regulation of the quorum sensing transcription factor AgrA by coenzyme A

Bakovic, J., Yu, B., Silva, D., Baczynska, M., Peak-Chew, S., Switzer, A., Burchell, L., Wigneshweraraj, S., Vandanashree, M., Gopal, B., Filonenko, V., Skehel, M., Gout, I.

Antioxidants 10:841. 2021

 

80. Novel insights into ATP stimulated cleavage of branched DNA and RNA substrates through structure-guided studies of the Holliday junction resolvase RuvX.

Thakur, M., Mohan, D., Singh, A. K., Agarwal, A., Gopal, B., Muniyappa, K.

J Mol Biol 433:167014. 2021

 

79. Draft genome sequence of the community associated Staphylococcus aureus sequence type 88strain LVP-7, isolated from an ocular infection.

Nadig, S., Murthy, S., Murali, V., Subramanya, H. S., Gopal, B., Vembar, S.

Resource Announcements 10: 00077-00021. 2021

 

78. Mycobacterium tuberculosis SufR responds to nitric oxide via its 4Fe-4S cluster and regulates Fe-S cluster biogenesis for persistence

In mice.

Anand, K., Tripathi, A., Shukla, K., Malhotra, N., Jamithireddy, A. K., Jha, R. K., Chaudhury, S. N., Rajmani, R. S., Ramesh, A.,

Nagaraja, V., Gopal, B., Nagaraju, G., Seshasayee,, A. S. N., Singh, A.

Redox Biology https://doi.org/10.1016/j.redox.2021.102062. 2021

 

 

77.Use of a molecular beacon based fluorescent method to assay uracyl DNA glycosylase (UNG) activity and inhibitor screening.

Mehta, A., Raj, P., Sundriyal, S., Gopal, B., Varshney, U.

BB Reports 26:100954. 2021

 

76. Structural and biochemical characteristics of two Staphylococcus epidermidis RNase J paralogues RNase J1 and RNase J2.

Raj, R., Nadig, S., Patel, T., Gopal, B.

J Biol Chem doi:10.1074/jbc.RA120.014876. 2020

 

75.Structural insights into the catalytic mechanism of Bacillus subtilis BacF.

Deshmukh, A., Gopal, B.

Acta Cryst F76:145-151. 2020

 

74. Evaluation of specificity determinants in Mycobacterium tuberculosis s /anti-s factor interactions.

Jamithireddy, A. K., Runthala, A., Gopal, B.

Biochem Biophys Res Comm 521:900-906. 2020

 

73. Destabiliation of Insulin hexamer in Water-Ethanol binary mixture.

Mukherjee S, Deshmukh AA, Mondal S, Gopal B, Bagchi B.

J Phys Chem B. 123:10365-10375. 2019

 

72. Selectivity among anti-s factors by Mycobacterium tuberculosis ClpX influences intracellular levels of Extracytoplasmic function

s factors .

Joshi, A. C., Kaur, P., Nair, R. K., Lele, D. S., Nandicoori, V. K., Gopal, B.

J. Bacteriol 25:pii e0048-18. 2019

 

71. The crystal structure of Mycobacterium tuberculosis high temperature requirement A protein reveals an autoregulatory mechanism.

Gupta, A. K., Behera, D., Gopal, B.

Acta Cryst F74:803-809. 2018

 

70. What gives an insulin hexamer its unique shape and stability? Role of ten confined water molecules.

Mukherjee, S., Mondal, S., Deshmukh, A. A., Gopal, B., Bagchi, B.

J. Phys. Chem B. 122:1631-1637. 2018

 

69. Characterization of the Staphylococcus epidermidis polynucleotide phosphorylase and its interactions with ribonucleases RNaseJ1 and RNaseJ2.

Raj, R., Mitra, S., Gopal, B.

Biochem Biophys Res Comm 495:2078-2084. 2018

 

68. The fused Snoal_2 domain of the Mycobacterium tuberculosis sigma factor σJ modulates promoter recognition.

Goutam, K., Gupta, A. K., Gopal, B.

Nucleic Acids Res 45:9760-9772. 2017

 

67. Determination of redox sensitivity in structurally similar biological redox sensors.

Jamithireddy, A. K., Samajdar, R. N., Gopal, B., Bhattacharyya, A. J.

J. Phys. Chem B 121:7005-7015. 2017

 

66. Design, synthesis and experimental validation of peptide ligand targeting Mycobacterium tuberculosis σ factors.

Vishwanath, S., Banerjee, S., Jamithireddy, A. K., Srinivasan, N., Gopal, B., Chatterjee, J.

Biochemistry 56:2209-2218. 2017

 

65.Probing the influence of non-covalent interaction networks identified by charge density analysis on the oxidoreductase BacC.

Kumar, P., Balaram, H., Guru Row, T. N., Gopal, B.

Protein Engg Des Select. 30:263-270.2017

 

64.The topology of the L-arginine exporter ArgO conforms to an Nin-Cout configuration in Escherichia coli: Requirement of the cytoplasmic N-terminal domain, functional helical interactions and an aspartate pair for ArgO function.

Pathania, A., Gupta, A. K., Dubey, S, Gopal, B., Sardesai, A. S.

J. Bacteriology 198: 3186-3199. 2016

 

63. A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains.

Shambat, S.M., Siemens, N., Monk, I. R., Disha Mohan B, Mukundan, S. Krishnan, K. C., Prabhakara, S., Snall, J., Kearns, A., Vandenesch, F., Svensson, M., Kotb, M., Gopal, B., Arakere, G., Norrby-Teglund, A.

Sci Reports 6: 31360-31372. 2016

 

62. Conformational features of the Staphylococcus aureus AgrA-promoter interactions rationalize quorum-sensing triggered gene expression.

Kalagiri, R., Fasim, A., Gopal, B.

Biochem Biophys Rep 6: 124-134. 2016

 

61.Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues

Shivastava, P., Navratna, V., Silla, Y., Dewangan, R. P., Pramanik, A., Chaudhary, S., Rayasam, G. V., Kumar, A., Ugarkar, B., Gopal, B., Ramachandran, S.

Sci Reports 6:30827-30844. 2016

 

60. Crystallographic studies of the extracytoplasmic function sigma factor SigJ from Mycobacterium tuberculosis

Goutam, K., Gupta, A. K., Gopal, B.

Acta Cryst. F71:946-950. 2015

 

59. Structural basis for the catalytic mechanism of homoserine dehydrogenase.

Navratna, V., Reddy, G. Gopal, B.

Acta Cryst. D71: 1216-1225. 2015

 

58. Influence of the AgrC-AgrA complex in the response time of Staphylococcus aureus quorum sensing.

Srivastava, S. K., Rajasree, K., Fasim, A., Arakere, G., Gopal, B.

J. Bacteriology 196: 2876-2888. 2014

 

57. Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA σ-anti-σ complex.

Shukla, J.K., Gupta, R., Thakur, K.G., Gokhale, R. S., Gopal, B.

Acta Cryst. D70: 1026-1036. 2014

 

56. Titania nanotube-modified screen printed carbon electrodes enhance the sensitivity in the electrochemical detection of proteins.

Mandal, S.S., Navratna, V., Sharma, P., Gopal, B., Bhattacharyya, A. J.

Bioelectrochemistry 98: 46-52. 2014

 

55. Bi-domain protein tyrosine Phosphatases reveal an evolutionary adaptation to optimize signal transduction.

Ahuja, L. G., Gopal, B.

Antioxidants & Redox Signalling 20: 2141-2159. 2014

 

54. Crystallization and preliminary X-Ray diffraction studies of Staphylococcus aureus homoserine dehydrogenase.

Navratna, V, Gopal, B.

Acta Cryst F69:1216-1219. 2013

 

53. Mycobacterium tuberculosis RsdA provides a conformational rationale for selective regulation of σ factor activity by proteolysis.

Jaiswal R K, Suryaprabha T, Manjeera G, Gopal B.

Nucleic Acids Res 41:3414-3423. 2013

 

52. The crystal structure of an amidohydrolase SACOL0085 from Methicillin Resistant Staphylococcus aureus COL.

Girish T S, Vivek B, Colaco M, Misquith S, Gopal B.

Acta Cryst F69:103-108. 2013

 

51. Structural insights into the role of Bacillus subtilis YwfH (BacG) in tetrahydrotyrosine synthesis.

Rajavel M, Perinbam K, Gopal B.

Acta Cryst D69:324-332. 2013

 

50. Analysis of conformational variation in macromolecular structural models.

Srivastava S K, Gayathri S, Manjasetty B A, Gopal B.

PLoS One. 2012;7(7):e39993. 2012

 

49. Inter-domain interactions influence the stability and catalytic activity of the bi-domain protein tyrosine phosphatase PTP99A.

Madan L L, Goutam K, Gopal B.

Biochem Biophys Acta. 2012 Aug;1824:983-90. 2012

 

48. Conformational basis for substrate recruitment in Protein Tyrosine Phosphatase 10D

Madan L L, Gopal B.

Biochemistry 50: 10114-10125. 2011

 

47. Modulation of catalytic activity in multi-domain protein tyrosine phosphatases

Madan L L, Veeranna S, Shameer K, Reddy C C S, Sowdhamini R, Gopal, B.

Plos One 6(9): e24766. 2011

 

46. Structure and nucleotide specificity of Staphylococcus aureus dihydrodipicolinate reductase (DapB).

Girish T S, Navratna V, Gopal B.

FEBS Letts. 585: 2561-2567. 2011

 

45. Conformational basis for substrate recognition and regulation of catalytic activity in Staphylococcus aureus

nucleoside di-phosphate kinase

Srivastava S K, Rajasree K, Gopal B

Biochem Biophys Acta (Proteins and Proteomics) 1814: 1349-1357. 2011

 

44. Structural Biology of Mycobacterium tuberculosis: The Indian Efforts

Arora A, Chandra N R, Das A, Gopal B, Mande S C, Prakash B, Ramachandran R, Sankaranarayanan R, Sekar K, Suguna K, Tyagi A K, Vijayan M.

Tuberculosis (Edinb) 91(5) : 456-468. 2011

 

43. PeptideMine A webserver for the design of peptides for protein peptide binding studies derived from protein-protein interactomes.

Shameer K , Madan L L, Veeranna S, Gopal B, Sowdhamini R .

BMC Bioinformatics 11 : 473. 2010

 

42. The crystal structure of Staphylococcus aureus metallopeptidase (Sapep) reveals large domain motions between the manganese bound and apo states.

Girish T S , Gopal B.

J. Biol. Chem 285, 29406-29415. 2010

 

41. Over-expression and purification strategies for recombinant multi-protein oligomers: A case study of Mycobacterium tuberculosis s/anti-s factor protein complexes

Thakur K G, Jaiswal R K, Shukla J K, Praveena T, Gopal B.

Prot. Exp. Purif. 74(2) : 223-230. 2010

 

40. Role of a PAS sensor domain in the Mycobacterium tuberculosis transcription regulator Rv1364c.

Jaiswal R K, Manjeera G, Gopal, B.

Biochem Biophys Res Comm 398, 342-349. 2010

 

39. Structural and biochemical basis for the redox sensitivity of Mycobacterium tuberculosis RslA

Thakur K G, Praveena T, Gopal B.

J. Mol. Biol.397, 1199-1208. 2010

 

38. Analysis of multiple crystal forms of Bacillus subtilis BacB suggests a role for a metal ion as a nucleant for crystallization.

Rajavel M, Gopal B.

Acta Cryst D. 66, 635-639. 2010

 

37. Inhibition of a protein tyrosine phosphatase using mesoporous oxides.

Kapoor S, Girish T S, Mandal S S, Gopal B, Bhattacharyya A J.

J. Phys. Chem B. 114: 3117-3121. 2010

 

36. X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate.

Chakrabarty K, Thakur G, Gopal B, Sarma S.

FEBS J. 277:697-712. 2010

 

35. Molecular Basis for the role of Staphylococcus aureus Penicillin Binding Protein 4 in antimicrobial resistance.

Navratna V, Nadig S, Sood V, Prasad K, Arakere G, Gopal B.

J. Bacteriology 192: 134-144. 2010

 

34. Mycobacterium tuberculosis Rv2704 is a member of YjgF/YER057c/UK114 family.

Thakur K G, Praveena T, Gopal B.

Proteins 78:773-778. 2010

 

33. Role of Bacillus subtilis BacB in the synthesis of the antibiotic bacilysin.

Rajavel M, Mitra A, Gopal B.

J. Biol. Chem 284:31882-31892. 2009

 

32. Structure-based phylogeny as a diagnostic for functional characterization of proteins with cupin fold

Agarwal G, Rajavel M, Gopal B, Srinivasan N.

PLoS One 4(5): e5736. 2009

 

31. Correlation between the sucrose synthase protein subfamilies, structure and expression in stress-derived Expressed Sequence Tag datasets.

Jayashree B, Pradeep R, Kumar A, Gopal B.

J. Proteomics Bioinformatics 1, 408-423. 2008

 

30. Refolding and simultaneous purification by three phase partitioning of recombinant proteins from inclusion bodies.

Raghava S, Barua B, Singh P K, Das M, Madan L L, Bhattacharyya S, Bajaj K, Gopal B, Varadarajan R, Gupta M N.

Protein Sci 17,:1987-1997. 2008

 

29. Structural and functional characterization of Staphylococcus aureus dihydrodipicolinate synthase.

Girish T S, Sharma E, Gopal B.

FEBS Letts 582,2923-2930. 2008

 

28. Conformational studies suggest that the double stranded b helix scaffold provides an optimal balance between protein stability and function.

Rajavel M, Kulkarni N N, Gopal B.

Prot. Pept. Letts 15, 244-249 2008

 

27. Addition of a polypeptide stretch at the N-terminus improves the expression, stability and solubility of recombinant protein tyrosine phosphatases from Drosophila melanogaster.

Madan L L, Gopal B

Prot. Exp. Purif.57, 234-243. 2008

 

26. Structural and biophysical studies on two promoter recognition domains of the extra-cytoplasmic function s factor sC from Mycobacterium tuberculosis.

Thakur K G, Joshi A M, Gopal B.

J. Biol. Chem 282, 4711-4718. 2008

 

25. The crystal structure of the catalytic domain of the chick retinal neurite inhibitor- Receptor Protein Tyrosine Phosphatase CRYP-2 / cPTPRO.

Girish T S, Gopal B.

Proteins 65,1011-1015. 2007

 

24. Crystallization and preliminary X-Ray diffraction studies on the bicupin YwfC from Bacillus subtilis

Rajavel M, Gopal B.

Acta Cryst F62, 1259-1262. 2006

 

23. Old fold in a new X-Ray diffraction dataset? Low-resolution molecular replacement using representative structural templates can provide phase information.

Rajavel M, Warrier T, Gopal B.

Proteins 64, 223-230 . 2006

 

22. Crystallization and preliminary X-Ray diffraction studies on the N- and C- terminal domains of the extra-cytoplasmic sigma factor SigC from Mycobacterium tuberculosis.

Thakur K G, Gopal B.

Acta Cryst F61, 779-781. 2005

 

21. Crystallization and Preliminary X-Ray diffraction studies on the catalytic domain of the of the chick neurite inhibitory factor CRYP-2.

Girish T S, Gopal B.

Acta Cryst F61, 381-383. 2005

 

20. The mechanism of upstream activation in the rrnB operon of Mycobacterium smegmatis is different from the Escherichia coli paradigm.

Arnvig K B, Gopal B, Papavinasasundaram K G, Cox R A, Colston M J.

Microbiology 151, 467-473. 2005

 

19. Crystal structure of a quercetin 2,3 dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s)

Gopal B, Madan L L, Betz S F, Kossiakoff A A.

Biochemistry 44, 193-201. 2005

 

18. A high affinity interaction between NusA and the rrn nut site in Mycobacterium tuberculosis.

Arnvig K B, Pennel S, Gopal B, Colston M J.

Proc. Natl. Acad. Sci (USA) 101, 8325-8330. 2004

 

17. Crystal Structure of the transcription elongation / antitermination factor NusA from Mycobacterium tuberculosis.

Gopal B, Haire L F, Gamblin S J, Dodson E J, Lane A N, Papavinasasundaram K G P, Colston M J, Dodson G.

J. Mol. Biol. 314, 1087-1095. 2001

 

16. Crystallization and preliminary X ray diffraction studies on the N-utilizing substance A (NusA) from Mycobacterium tuberculosis.

Gopal B, Papavinasasundaram K G P, Colston M J, Dodson G, Haire L F.

Acta Cryst D57, 1187-1188. 2001

 

15. Spectroscopic and thermodynamic characterization of the transcription antitermination factor NusE and its interaction with NusB from Mycobacterium tuberculosis.

Gopal B, Papavinasasundaram K G P, Colston M J, Dodson G, Major S, Lane A N.

Biochemistry 40,Jan 30 920-928. 2001

 

14. Tackling both the player and the ball: Lessons from crystallographic studies on the N-utilizing substance B (NusB) from Mycobacterium tuberculosis.

Haire L F, Gopal B.

J. Crystal Growth 232, 361-367. 2001

 

13. Variability of calcium binding to EF-hand motifs probed by Electrospray Ionization Mass Spectrometry.

Moorthy A K, Singh S K, Gopal B, Surolia A, Murthy M R N.

J. Am. Soc. Mass. Spectrom. 12, 1296-1301. 2001

 

12. Crystal structure of NusB from Mycobacterium tuberculosis.

Gopal B, Haire L F, Lane A N, Major S, Brannigan J A, Cox R A, Colston M J, Smerdon S J, Dodson G.

Nature Struct Biol 7, 475-478. 2000

 

11. Crystallization and preliminary X-ray diffraction studies on the N-utilizing substance B (NusB) from Mycobacterium tuberculosis.

Gopal B, Cox R A, Colston M J, Dodson G G, Smerdon S J, Haire L F.

Acta Cryst D56, 64-66. 2000

 

10. Structural and thermodynamic studies on protein stability.

Gopal B.

J. Ind Inst of Sci., 79, 551-553. 1999

 

9. Thermodynamics of target peptide recognition by Calmodulin and a Calmodulin analogue : Implications for the role of the Central Linker.

Moorthy A K, Gopal B, Satish P R, Bhattacharya S, Bhattacharya A, Murthy M R N, Surolia A.

FEBS Letts 461, 19-24. 1999

 

8. Temperature dependent cell transformation in a Calcium binding Protein from Entamoeba histolytica.

Moorthy A K, Gopal B, Gopimohan C, Murthy M R N.

Current Science 76, No. 7, 855-856. 1999

 

7. Disulfide Engineering at the Dimer Interface of Lactobacillus casei Thymidylate Synthase : Crystal Structure of the T155C /E188C /C244T mutant.

Velanker S S, Gokhale R S, Ray S S Gopal B, Parthasarathy S, Santi D V, Balaram P, Murthy M R N.

Protein Science 8, 930-933. 1999

 

6. Cavity Creating Mutation at the Dimer Interface in Plasmodium falciparum Triosephosphate isomerase : Restoring Protein Stability by Disulfide Crosslinking of Subunits.

Gopal B, Ray S S, Gokhale R S, Balaram H, Murthy M R N, Balaram P.

Biochemistry 38, 478-486. 1999

 

5. Effect of amino acid substitutions at the subunit interface on the stability and aggregation properties of a dimeric protein: role of Arg 178 and Arg 218 at the Dimer interface of thymidylate synthase.

Prasanna V, Gopal B, Murthy M R N, Santi D V, Balaram P.

Proteins 34: 356-368. 1999

 

4. Induction of a spectrascopically defined .transition by Guanidium hydrochloride on a recombinant calcium binding protein from Entamoeba histolytica.

Gopal B, Krishna Rao J V, Thomas C J, Bhattacharya A, Bhattacharya S, Murthy M R N, Surolia A.

FEBS Letts 441, 71-76. 1998

 

3. Crystals of a Thymidylate Synthase mutant offer insights into crystal packing and protein plasticity.

Gopal B, Prasanna V, Parthasarathy S, Santi D V, Balaram P, Murthy M R N.

Current Science 75, No. 3, 299-304. 1998

 

2. Crystallization and preliminary X-ray studies of a recombinant calcium binding protein from Entamoeba histolytica.

Gopal B, Suma R, Murthy M R N, Bhattacharya A , Bhattacharya S.

Acta Cryst.D54 1442-1445. 1998

 

1. Thermodynamics of metal ion binding and denaturation of a Calcium Binding Protein from Entamoeba histolytica.

Gopal B, Swaminathan C P, Bhattacharya S, Bhattacharya A, Murthy M R N, Surolia A.

Biochemistry 36, No. 36, 10910-10917. 1997